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Journal of Microbiology
Vol. 52, No.
1, 2014; Page: 64 - 70

Cyclic dipeptides from lactic acid bacteria inhibit the proliferation of pathogenic fungi

Min-Kyu Kwak, Rui Liu, Min-Kyu Kim, Dohyun Moon, Andrew HyoungJin Kim, Sung-Hyun Song, Sa-Ouk Kang

Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul, 151-747, Republic of Korea.


Lactobacillus plantarum LBP-K10 was identified to be the most potent antifungal strain from Korean traditional fermented vegetables. The culture filtrate of this strain showed remarkable antifungal activity against Ganoderma boninense. Five fractions from the culture filtrate were observed to have an inhibitory effect against G. boninense. Also, the electron ionization and chemical ionization indicated that these compounds might be cyclic dipeptides. Of the five active fractions, two fractions showed the most significant anti-Ganoderma activity, and one of these fractions inhibited the growth of Candida albicans. These compounds were identified to be cis-cyclo(l-Val-l-Pro) and cis-cyclo(l-Phe-l-Pro), as confirmed by X-ray crystallography.

Keywords: Lactobacillus plantarum LBP-K10; culture filtrate, cis-cyclo(l-Val-l-Pro); cis-cyclo(l-Phe-l-Pro); Ganoderma boninense ; Candida albicans



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