3

 

Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Microorganisms
Research on Microbes
Database
Bibliography
Publications
Library
E-Resources
Microbiology Experts
Events
Online Submission
Access Statistics

Site Visitors

blog tracking


 
Current Opinion in Toxicology
Volume 29, 2022, Pages 19-24

Physiological hormesis and hormetins in biogerontology

Suresh I.S. Rattan

Department of Molecular Biology and Genetics, Aarhus University, Denmark.

Abstract

Research on the biology of aging and possibilities of interventions has gained a significant push forward by incorporating the concept of mild stress-induced physiological hormesis. Mild stress induced-activation of adaptive and protective pathways in cells and organisms has numerous health-promoting, aging-modulatory and lifespan-extending effects. Moderate and repeated physical exercise is the paradigm for physiological hormesis. Molecular mechanisms for the action of hormetins comprise a cascade of primary stress response pathways, including oxidative stress response, heat shock response, unfolded protein stress response, autophagy, DNA damage response, inflammatory response and sirtuin activation response. Hormetin-based strengthening of the organismic ability of homeodynamics or dynamic homeostasis is a promising holistic approach towards health maintenance, recovery, and promotion for healthy aging and longevity.

Keywords: Aging, Longevity, Homeostasis, Homeodynamics, Stress response.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution