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Materials Today: Proceedings
Volume 42, 2021, Pages 2277-2284

Response surface methodology: A review on its applications and challenges in microbial cultures

Sura Jasem MohammedBreiga, Khalid Jaber Kadhum Lutib

Biochemical Engineering Department, Al-Khwararizmi College of Engineering, University of Baghdad, Baghdad, Iraq.


Response surface methodology (RSM) was effectively used for the optimization and modelling of a wide variety of microbial products. This method is a combination of statistical and mathematical technique for model construction, assessing the effect of several independent variables and getting optimum values of variables. The purpose of this paper is to review recent research on the utilization of response surface methodology in the fermentation process to optimize microbial activities and products. In addition to discussing the usefulness of using this method, this article also reviews the current information and the hypothetical concepts as well as the main steps for the application of RSM in microbial cultures. Furthermore, this paper attempts to show the recent implementing studies as well as the challenges that may occur on using response surface methodology as an effective technique to develop the performance of industrial microbial strains.

Keywords: Response surface methodology, Microbial products, Challenges, Optimization, Secondary metabolites, Primary metabolites.

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