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Applied Mathematical Modelling
Vol. 39 (7), 2015, Pages: 2048–2055

Analysis and application of biological robustness as performance index in microbial fermentation

Lei Wang, Guanming Cheng, Enmin Feng, Tao Su, Zhilong Xiu

School of Mathematical Science, Dalian University of Technology, Dalian 116024, Liaoning, China.


Robustness is the fundamental organizational principle of biological systems. Understanding robustness and its intrinsic properties will provide us with a more profound understanding of biological systems, their anomalies, and countermeasures. In this paper, for the microbial fermentation case, we generally present a way to design the performance index to identify the system structure by using the qualitative description of biological robustness. In the specific example, we give the numerical results for inferring the possible ways of transport across the cell membrane by using serial and parallel algorithm respectively, which show that biological robustness’ power for applications.

Keywords: Biological robustness; Microbial fermentation; Performance index; Algorithm.

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