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Trends in Cancer
Volume 8 (5), 2022, 369-383

Coagulome and the tumor microenvironment: an actionable interplay

Antoine Galmiche1,2, Janusz Rak3, Lubka T. Roumenina4, Zuzana Saidak1,2

Laboratoire de Biochimie, Centre de Biologie Humaine, CHU Sud, Amiens, France.

Abstract

Human tumors often trigger a hypercoagulable state that promotes hemostatic complications, including venous thromboembolism. The recent application of systems biology to the study of the coagulome highlighted its link to shaping the tumor microenvironment (TME), both within and outside of the vascular space. Addressing this link provides the opportunity to revisit the significance of biomarkers of hemostasis and assess the communication between vasculature and tumor parenchyma, an important topic considering the advent of immune checkpoint inhibitors and vascular normalization strategies. Understanding how the coagulome and TME influence each other offers exciting new prospects for predicting hemostatic complications and boosting the effectiveness of cancer treatment.

Keywords: coagulome, venous thromboembolism, tumor microenvironment, anticoagulants, biomarkers.

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