Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Microorganisms
Research on Microbes
Database
Bibliography
Publications
Library
E-Resources
Microbiology Experts
Events
Online Submission
Access Statistics

Site Visitors

blog tracking


 
BioEssays : news and reviews in molecular, cellular and developmental biology
Vol. 31, No: 12, 2009, Pages: 1309 - 17


Iron metabolism: microbes, mouse, and man

Latunde-Dada GO

King's College London, Nutritional Sciences Division, School of Biomedical and Health Sciences, Franklin-Wilkins Building, London SE1 9NH, United Kingdom.

Abstract

Recent advances in research on iron metabolism have revealed the identity of a number of genes, signal transduction pathways, and proteins involved in iron regulation in mammals. The emerging paradigm is a coordination of homeostasis within a network of classical iron metabolic pathways and other cellular processes such as cell differentiation, growth, inflammation, immunity, and a host of physiologic and pathologic conditions. Iron, immunity, and infection are intricately linked and their regulation is fundamental to the survival of mammals. The mutual dependence on iron by the host and invading pathogenic organisms elicits competition for the element during infection. While the host maintains mechanisms to utilize iron for its own metabolism exclusively, pathogenic organisms are armed with a myriad of strategies to circumvent these measures. This review explores iron metabolism in mammalian host, defense mechanisms against pathogenic microbes and the competitive devices of microbes for access to iron.

Keywords:iron metabolism have revealed the identity of a number of genes,cell differentiation, growth, inflammation, immunity, and a host of physiologic and pathologic conditions.


 

 

 
Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution