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Mims' Pathogenesis of Infectious Disease
2015, Pages: 67–93

Encounter of Microbes with Phagocytic Cells

Anthony A. Nash, Robert G. Dalziel, J. Ross Fitzgerald

School of Environment and Chemical Engineering, North China Electric Power University, Beijing 102206, PR China.


In this chapter we describe the key events associated with phagocytosis, a critical immune activity required for host innate resistance to infection. In response to phagocytosis, microbial pathogens have evolved a myriad of ways to interfere with this process and avoid killing. In fact, some bacteria have evolved the capacity to survive and proliferate within phagocytic cells. We provide selected examples of the different mechanisms involved in pathogen avoidance of phagocytosis, and also discuss how defects in phagocytic cells can predispose to infection.

Keywords: phagocyte; macrophage; neutrophil; phagosome; endocytosis; lysosomal fusion; neutropenia; chronic granulomatous disease.

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