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Natural Product Communications
Vol. 6, No: 12, 2011, Pages: 1915 - 6

Potent toxic macrocyclic trichothecenes from the marine-derived fungus Myrothecium verrucaria Hmp-F73

Zhao L, Liu L, Wang N, Wang SJ, Hu JC, Gao JM

Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.


Activity-guided fractionation of a methanol extract from the culture broth of Myrothecium verrucaria Hmp-F73, a fungus associated with the sponge Hymeniacidon perleve, afforded six macrocyclic trichothecenes, verrucarin J (1), 8-hydroxyverrucarin J (2), verrucarin A (3), 8-acetoxyroridin H (4), isororidin E (5), and roridin E (6), along with trichoverrin B (7). All seven metabolites displayed potent toxicity to the brine shrimp (Artemia salina). In addition, compounds 2, 3, and 6 showed weak phytotoxic activities against lettuce seeds. A preliminary structure-activity relationship of the metabolites is also discussed.

Keywords:fractionation of a methanol extract from the culture broth of Myrothecium verrucaria Hmp-F73,macrocyclic trichothecenes, verrucarin,potent toxicity to the brine shrimp.


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