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Journal of Hazardous Materials
Volume 430, 2022, 128366

Metabolic and DNA checkpoints for the enhancement of Al tolerance

Joćo Antonio Siqueira, Marcelle Ferreira Silva, Thiago Wakin, Adriano Nunes-Nesi, Wagner L. Araśjo

Departamento de Biologia Vegetal, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.


Acidic soils are a major limiting factor for food production in many developing countries. High concentrations of soluble Al cations, particularly Al3+, inhibit cell division and root elongation in plants. Al3+ damages several biomolecules, including DNA, impairing gene expression and cell cycle progression. Notably, the loss-of-function mutants of DNA checkpoints may mediate Al tolerance. Furthermore, mitochondrial organic acids play key roles in neutralizing Al3+ within the cell and around the rhizosphere. Here, we provide knowledge synthesis on interactions between checkpoints related to mitochondrial organic acid homeostasis and DNA integrity mediating Al tolerance in land plants. These interactions, coupled with remarkable advances in tools related to metabolism and cell cycle, may facilitate the development of next-generation productive crops under Al toxicity.

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