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Current Opinion in Chemical Engineering
Volume 22, 2018, Pages 244-252

Model-based tools for optimal experiments in bioprocess engineering

Vinzenz Abt2, Tilman Barz1, Mariano Nicolas Cruz-Bournazou2, Christoph Herwig3, Paul Kroll3, Johannes Möller4, Ralf Pörtner4, René Schenkendorf5,6

AIT Austrian Institute of Technology GmbH, Center of Energy, Vienna, Austria.


Currently applied methods for characterization and optimization of bio-pharmaceutical processes are still strongly empirical. This often involves Design of Experiment (DoE) methods that require a large number of time-consuming experiments and can hardly fulfill the requirements of ‘Quality by Design’ (QbD). Linking mathematical models with experimental methods is seen as an efficient strategy that significantly reduces development time and costs. Furthermore, if combined with advanced Process Analytical Technology (PAT), higher automation and more efficient workflows can be established along the product lifecycle. This contribution presents the state of the art of model-based tools for experimental design and gives an outlook on future trends in the field of bio-process engineering.


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