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Systems and Synthetic Biology
2015, Pages: 341-356

Metabolic Engineering of Microorganisms for Biosynthesis of Antibiotics

Vijai Singh, Indra Mani, Dharmendra Kumar Chaudhary

Synth-Bio Group, Institute of Systems & Synthetic Biology, University of Evry, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbruères, 91030, ÉVRY, France.


Number of microorganisms produces antibiotics that can inhibit or kill the other microbes. The production of some antibiotics is not sufficient in native host rather difficult to synthesize chemically and to extract in large amounts for commercialization. Metabolic engineering plays an increasingly significant role in the production of antibiotics and its precursors. Thus, we engineer biosynthetic pathways in desire host for the production of sufficient quantity of antibiotics. In this chapter, we illustrated bioengineering of different microbes using synthetic biology and metabolic engineering approaches for production and regulation of antibiotics.

Keywords: Biosynthetic pathway, Disease, Antibiotics, Metabolic engineering, Gene regulation, Synthetic biology.

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