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Bioresource Technology
Volume 326, 2021, 124771

Engineering interventions in enzyme production: Lab to industrial scale

Ayon Tarafdara,1, Ranjna Sirohib,c,d,1, Vivek Kumar Gaure, Sunil Kumarc, Poonam Sharmaf, Sunita Varjanig, Hari Om Pandeya, Raveendran Sindhuh, Aravind Madhavani, Reshmy Rajasekharanj, Sang Jun Simd

Divison of Livestock Production and Management, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243 122, India.


Commercial enzyme production has gained popularity due to its extensive applications in traditional and modern industrial sectors. Rigorous research activities are being conducted worldwide to make the enzyme production system more efficient, cost-effective and hence, sustainable. To overcome the lacunae in earlier enzyme production methods, new engineering interventions are being introduced to meet the growing demand for industrial enzymes. This review focuses initially on the current global scenario of the enzyme market followed by a discussion on different bioreactor design approaches. The use of novel membrane based, airlift and reciprocating plate bioreactors along with the emergence of micro-reactors have also been discussed. Further, the review covers different modelling and optimization strategies for the enzyme production process including advanced techniques like neural networks, adaptive neuro-fuzzy inference systems and genetic algorithms. Finally, the required thrust areas in the enzyme production sector have been highlighted with directions for future research.

Keywords: Bioreactors, Microreactors, Modeling, Neural network, Genetic algorithm.

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