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Journal of Materials Chemistry B
3, 2015; Pages: 1157-1162

Anti-biofouling surface with sub-20 nm heterogeneous nanopatterns

Lei Shen, Jun Xie, Juan Tao and Jintao Zhu

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China

Abstract

We develop a novel heterogeneous pattern with nanometer-sized spots surrounded with a bio-inert matrix by using a diblock copolymer thin film. The nanopattern with features down to 20 nm is highly resistant to protein adsorption and cell adhesion. By providing a domelike topography similar to biologically relevant size, such a heterogeneous nanopattern demonstrates an excellent anti-biofouling property to control protein–surface and cell–surface interactions at the molecular level.

Graphical abstract

 
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