Gut Microbiota and the Liver: Interaction Shaping Interactome

Priti Devi^a,b,#, Azka Khan^a,#, Partha Chattopadhyay^a,b,#, Aarushi Garg^a,#

INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India.

The human gut hosts 10–100 trillion of microbes, including bacteria, virus, fungi and archaea, many of them are directly or indirectly involved with host homeostasis. The liver is constantly exposed to the microbial endotoxins, metabolites, and microbes through hepatic circulation. Dysbiosis in the gut microbiota leading to activation of immune and inflammatory responses in liver and results in various liver diseases. In order to restore the gut microbiota, various therapeutic approaches, such as probiotics, prebiotics, symbiotics are available. This article mainly emphasize the dynamic interaction of gut microbiota and liver, consequent liver diseases, and possible therapeutic approaches.

Keywords: Disease, Dysbiosis, Eubiosis, Immune response, Interaction, Liver, Microbiota, NAFLD, RNA virus, Therapeutics.