Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Research on Microbes
Microbiology Experts
Online Submission
Access Statistics

Site Visitors

blog tracking

Chemical Data Collections
Volume 32, 2021, 100648

Synthesis, characterization, in silico molecular modeling, anti-diabetic and antimicrobial screening of novel 1-aryl-N-tosyl-1H-tetrazole-5-carboxamide derivatives

Sekar Selvarasua, Pazhamalai Srinivasana, Gopalakrishnan Mannathusamya, Boobalan Maria Susaib

Department of Chemistry, Annamalai University, Annamalai Nagar, Chidambaram 608002, Tamil Nadu, India.


Tetrazole carboxamide is one of the important categories of heterocyclic compounds that acquire a broad spectrum of biological and medicinal properties. The present work deals with the synthesis and characterization of some novel 1-aryl-N-tosyl-1H-tetrazole-5-carboxamide derivatives. All the synthesized compounds were characterized by FT-IR, 1HNMR, 13CNMR, elemental and mass spectrometric analysis. The compounds were evaluated for their in-vitro and in-vivo anti-diabetic and antimicrobial activity. Synthesized compound 3i 10 mg/kg exhibited maximum glucose lowering effect in diabetic rats compared to the other ten doses. All the synthesized compounds were evaluated in ADME properties and in-silico docking studies against proteins (PDB code-1E7U, 3KP3).

Keywords: Tetrazole carboxamide, Molecular docking, Anti-diabetic and antimicrobial activity, ADME property.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution