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Biological Control
Volume 140, 2020, 104126

Complete genome sequence of the mountain-cultivated ginseng endophyte Burkholderia stabilis and its antimicrobial compounds against ginseng root rot disease

Hoki Kima, Tapan Kumar Mohantab, Young-Hwan Parkc, Soo-Chul Parkd, Gnanendra Shanmugama, Jin-Soo Parke, ,Junhyun Jeona, Hanhong Baea

Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea.


Ginseng (Panax ginseng Meyer) is one of the most important perennial medicinal plants. Ginseng is vulnerable to life-threatening diseases like root rot, blight, damping off, and spotting diseases because of its long cultivation period. Chemical control has numerous drawbacks for the plant and environment. Therefore, there is an immediate demand to replace the chemical agents with biological agents. We isolated and screened the bacterial endophytes from mountain-cultivated ginseng plants to use as them as biocontrol agents against ginseng pathogens. The bacterial endophyte Burkholderia stabilis EB159 (PG159, GenBank accession no. KU170189) was found to be the most effective against ginseng pathogens. Potential metabolites were isolated from a culture extract of PG159, and validated through spectral data analysis, which included UV, MS and NMR, and suggested that the role of pyrrolnitrin operates through the chromosomal prnABCD operon (5.59 kb). The whole genome sequence of PG159 showed significant similarity to those of the two available strains of B. stabilis. Overall, PG159 has great potential as a biocontrol agent against ginseng pathogens.

Keywords: Bacterial endophyte, Burkholderia stabilis, Genome sequence, Ginseng pathogen, Pyrrolnitrin.

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