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Bioorganic & Medicinal Chemistry Letters
Vol. 25; No. 1; 2015; Pages: 67-69

A potent antimicrobial compound isolated from Clathria cervicornis

Xiuxiu Suna, Shi Suna, Christopher Ferenceb, Wenjun Zhua, Ninghui Zhoua, Yifan Zhanga, Kequan Zhoua

Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, United States


The sponge of Clathria cervicornis is commonly used in traditional medicine. This study aims to identify the active compound in C. cervicornis and to evaluate its antimicrobial activity. The purified active compound was determined to be crambescidin 800 and was found to be highly active against Acinetobacter baumannii (minimal inhibitory concentration, MIC = 2 μg/ml), Klebsiella pneumoniae (MIC = 1 μg/ml) and Pseudomonas aeruginosa (MIC = 1 μg/ml). A potent antimicrobial compound, crambescidin 800, was isolated in Clathria cervicornis. It is extremely active against three common pathogenic bacteria.

Keywords:Natural antimicrobial; Clathria cervicornis; Crambescidin 800; Antimicrobial activity; Minimal inhibitory concentration .



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