Genetics
of Streptomyces rimosus, the Oxytetracycline Producer
Hrvoje Petkovi,1 John Cullum,2
Daslav Hranueli,3 Iain S. Hunter,4 Nataa
Peri-Concha,5 Jasenka Pigac,6 Arinthip
Thamchaipenet,7 Duica Vujaklija,6 and
Paul F. Long5*
The School of Pharmacy, University of London, 29/39 Brunswick
Square, London WC1N 1AX, United Kingdom.
Abstract
From a genetic standpoint, Streptomyces
rimosus is arguably the best-characterized industrial
streptomycete as the producer of oxytetracycline and other
tetracycline antibiotics. Although resistance to these antibiotics
has reduced their clinical use in recent years, tetracyclines
have an increasing role in the treatment of emerging infections
and noninfective diseases. Procedures for in vivo and in
vitro genetic manipulations in S. rimosus have
been developed since the 1950s and applied to study the
genetic instability of S. rimosus strains and for
the molecular cloning and characterization of genes involved
in oxytetracycline biosynthesis. Recent advances in the
methodology of genome sequencing bring the realistic prospect
of obtaining the genome sequence of S. rimosus
in the near term.
Keywords:
Streptomyces rimosus;streptomycete;oxytetracycline;tetracycline
antibiotics;genetic manipulations;oxytetracycline biosynthesis;methodology
of genome;taxonomy.
Corresponding author: Tel 44-20-77535868; Fax
44-20-77535868.
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