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Neuro Endocrinol Lett.
February 7, 2012. [Article in press]

Staphylococcus aureus causes not only nosocomial but also community acquired bacterial meningitis.




Abstract

OBJECTIVE:

Staphylococcus aureus is a well-known pathogen responsible for hospital acquired meningitis but among community acquired bacterial meningitis (CAM), this pathogen is rare. The aim of the study was to compare Staphylococcus aureus CAM to other bacterial meningitis cases and assess risk factors and outcome.

METHODS:

Among 293 cases of community bacterial meningitis within national hospital based survey in 1990-2010, etiology, risk factors and outcome between group of meningitis due to Staphylococcus aureus and other etiology patients group were compared. Differences were assessed by univariate analysis. Chi-square test, and Fisher's exact test computerized with the open source statistical package "R" were used and p-value <0.05 was considered statistical significant.

RESULTS:

Among 293 cases of CAM within 20 years in Slovakia, 14 cases of Staphylococcus aureus neuroinfections occurred in the community. Community acquired meningitis due to Staphylococcus aureus occurred significantly more frequently among diabetic patients (28.6% vs. 6.1%; p=0.01), those with otitis and/or sinusitis (50% vs. 18.6%; p=0.01) or in sepsis patients (35.7% vs. 12.0%; p=0.03). Meningitis due to Staphylococcus aureus was associated with significantly higher mortality (35.7% vs. 11.5%; p=0.002) that in CAM due to other pathogens.

CONCLUSION:

S. aureus is an emerging pathogens, causing not only postsurgical or nosocomial meningitis but also community acquired meningitis and is associated with unacceptably higher mortality (up to 40%).

 

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