7 8 9 3 3 7
Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Research on Microbes
Microbiology Experts
Online Submission
Access Statistics

Site Visitors

blog tracking

Pesticide Biochemistry and Physiology
Volume 150, 2018, Pages 59-65

Notopterygium incisum extract and associated secondary metabolites inhibit apple fruit fungal pathogens

Lin Xiaoa, Yuan-Ming Zhoub, Xiang-Fei Zhanga, Feng-Yu Dua

College of Chemistry and Pharmacy, Qingdao Agricultural University, Changcheng Road 700, Qingdao, Shandong 266109, PR China.


In the search for antifungal lead compounds from natural resources, Notopterygium incisum, a medicine plant only distributed in China, showed antifungal potential against apple fruit pathogens. Based on the bioassay-guided isolation, chromatography fraction 6 of the ethyl acetate partition exhibited significant in vitro and in vivo antifungal activities against apple fruit pathogens. Furthermore, nine antifungal secondary metabolites, including five linear furocoumarins (1–5), two phenylethyl esters (6–7), one falcarindiol (8), and one sesquiterpenoid (9), were isolated and elucidated from fraction 6. Compound 5 is a new metabolite, and 9 isolated from the genus Notopterygium for the first time. The purified compounds (1–9) were firstly reported to exhibit antifungal activities against apple fruit pathogens of Colletotrichum gloeosporioides and Botryosphaeria dothidea with the MIC values ranging from 8 to 250 mg L−1, especially 8 of 16 and 8 mg L−1, respectively. Moreover, 8 could inhibit the spore germination and new sporulation of B. dothidea, as well as enhance the membrane permeabilization of B. dothidea spores. This was the first investigation for the antifungal components against apple fruit pathogens from Notopterygium incisum, which has great potential to be developed into bio-fungicides.

Graphical abstract

Keywords: Notopterygium incisum, Antifungal activity, Apple fruit pathogens, Secondary metabolites.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution