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Journal of Photochemistry and Photobiology
Volume 8, 2021, 100079

Pathogen reduction technology for blood component: A promising solution for prevention of emerging infectious disease and bacterial contamination in blood transfusion services

Hong Liua, Xun Wanga

Department of Transfusion-transmitted infectious Disease, Institute of Blood Transfusion, Shanghai Blood Center, 1191 Hong Qiao Rd, Shanghai, China.


With the rapid evolving of emerging pathogens and residual risk of bacterial contamination in platelets, they continue to pose a constant threat to the safety of blood supply despite effort implemented to mitigate such risk via conventional measures and testing. Three photochemical based advanced pathogen reduction technology (PRT) that utilize amotosalen, riboflavin and UVC only offer some of the unique advantages over conventional approaches. They have demonstrated superior pathogen reduction capability against various emerging viruses, bacteria, parasites and leukocytes, as well as acceptable safety and clinical efficacy based on reports, studies and clinical trials. Although concern related to cost and adverse transfusion reaction of PRT application remains, with further study and continue improvement, future PRT will continue to play a paramount role in assuring the safety of blood and blood products.

Keywords: Pathogen reduction technology, PR system, Pathogen reduction, Emerging infectious disease, Transfusion-transmitted infection, Blood safety, Virus, Bacteria, Parasite, Leukocyte, Cost.

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