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Science
Vol.
336, No. 6086, 2012; Pages: 1262 - 1267

Host-Gut Microbiota Metabolic Interactions

Jeremy K. Nicholson, Elaine Holmes, James Kinross, Remy Burcelin, Glenn Gibson, Wei Jia, Sven Pettersson

Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

Abstract

The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.

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