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Trends in Molecular Medicine
Volume 27 (7), 2021, Pages 624-626

Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals

Xiao-JingGuan1,2,3, You-Ying Zhang1,2,3, Xiao Zheng1,2, Hai-Ping Hao1,2

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China.

Abstract

Host–microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that coordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy.

Keywords: nuclear receptors, host–microbe interaction, microbial metabolite, drug discovery, target identification.

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