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Biotechnology Advances
Volume 45, 2020, 107649

Microbial cell engineering to improve cellular synthetic capacity

Qiang Dinga,b, Wenwen Diaoa,b, Cong Gaoa,b, Xiulai Chena,b, Liming Liua,b,c

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.


Rapid technological progress in gene assembly, biosensors, and genetic circuits has led to reinforce the cellular synthetic capacity for chemical production. However, overcoming the current limitations of these techniques in maintaining cellular functions and enhancing the cellular synthetic capacity (e.g., catalytic efficiency, strain performance, and cell-cell communication) remains challenging. In this review, we propose a strategy for microbial cell engineering to improve the cellular synthetic capacity by utilizing biotechnological tools along with system biology methods to regulate cellular functions during chemical production. Current strategies in microbial cell engineering are mainly focused on the organelle, cell, and consortium levels. This review highlights the potential of using biotechnology to further develop the field of microbial cell engineering and provides guidance for utilizing microorganisms as attractive regulation targets.

Keywords: Cellular synthetic capacity, Microbial cell engineering, Organelle level, Cell level, Consortium level.

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