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Microbial Pathogenesis
Volume 128, 2019, Pages 171-177

Bacteriocins: Classification, synthesis, mechanism of action and resistance development in food spoilage causing bacteria

Rashmi Kumariyaa, Anita Kumari Garsab, Y.S.Rajputc, S.K.Soodc, Nadeem Akhtard, Seema Patele

Protein Expression and Purification Facility, Advanced Technology Platform Centre, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, 121001, India.


Huge demand of safe and natural preservatives has opened new area for intensive research on bacteriocins to unravel the novel range of antimicrobial compounds that could efficiently fight off the food-borne pathogens. Since food safety has become an increasingly important international concern, the application of bacteriocins from lactic acid bacteria that target food spoilage/pathogenic bacteria without major adverse effects has received great attention. Different modes of actions of these bacteriocins have been suggested and identified, like pore-forming, inhibition of cell-wall/nucleic acid/protein synthesis. However, development of resistance in the food spoilage and pathogenic bacteria against these bacteriocins is a rising concern. Emergence and spread of mutant strains resistant to bacteriocins is hampering food safety. It has spurred an interest to understand the bacteriocin resistance phenomenon displayed by the food pathogens, which will be helpful in mitigating the resistance problem. Therefore, present review is focused on the different resistance mechanisms adopted by food pathogens to overcome bacteriocin.

Graphical abstract

Keywords: Bacteriocins, Food pathogens, Resistance development, Cell wall, Cell membrane, Membrane receptors.

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