Two new compounds with antimicrobial activities from the seeds of Voacanga africana
Yifeng Niu, Chen Yang, Jing Zhou, Shen Huang, Jiajia Liu
Department of Pharmacy, School of Chemistry and Chemical Engineering, Central South University, Hunan, 410012, PR China.
Two new compounds, (R)-4-(2-methylpentyl)-4H-dithieno[2,3-b:3′,2′-e]pyran (1) and 4-(2-ethylbutyl)-4H-dithieno[2,3-b:3′,2′-e]pyran (2) were extracted from the seeds of Voacanga africana. The molecular structures of these compounds were measured with the help of broad spectroscopic (1D and 2D-NMR, IR, ESI-TOF-MS, HR-MS) analyses. The primary pharmacological operations of these compounds were brought to evaluation by applying the antibacterial extrasomatic test. The results revealed that compound 1and 2 were in an effective position to stop the growth of Escherichia coli, Streptococcusand Salmonella typhi. On the other hand, the inhibitory impacts on Staphylococcus aureus as well as Pseudomonas aeruginosa were not apparent.
Keywords: Thiophene compounds; Voacanga; Antibiotic.