Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Research on Microbes
Microbiology Experts
Online Submission
Access Statistics

Site Visitors

blog tracking

International Journal of Biological Macromolecules
Vol. 87, 2016, Pages: 460–465

Shape and size engineered cellulosic nanomaterials as broad spectrum anti-microbial compounds

Priyanka R. Sharma, Sunil Kamble, Dhiman Sarkar, Amitesh Anand, Anjani J. Varma

CSIR-National Chemical Laboratory, Polymer Science & Engineering Division, Dr. Homi Bhabha Road, Pune 411008, India.


Oxidized celluloses have been used for decades as antimicrobial wound gauzes and surgical cotton. We now report the successful synthesis of a next generation narrow size range (25–35 nm) spherical shaped nanoparticles of 2,3,6-tricarboxycellulose based on cellulose I structural features, for applications as new antimicrobial materials. This study adds to our previous study of 6-carboxycellulose. A wide range of bacteria such asEscherichia coliStaphloccocus aureusBacillus subtilis and Mycobacterium tuberculosis (non-pathogenic as well as pathogenic strains) were affected by these polymers in in vitro studies. Activity against Mycobacteria were noted at high concentrations (MIC99 values 250–1000 μg/ml, as compared to anti-TB drug Isoniazid 0.3 μg/ml). However, the broad spectrum activity of oxidized celluloses and their nanoparticles against a wide range of bacteria, including Mycobacteria, show that these materials are promising new biocompatible and biodegradable drug delivery vehicles wherein they can play the dual role of being a drug encapsulant as well as a broad spectrum anti-microbial and anti-TB drug.

Keywords: Tricarboxycellulose; Cellulose; Spherical nanoparticles; Anti-microbial.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution