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Natural Product Research: Formerly Natural Product Letters
Vol. 29, No. 3, 2015, Pages: 239-246

Isolation and structural elucidation of novel antimicrobial compounds from maggots of Chrysomyis megacephala Fabricius

Jiayu Gao, Wenyuan Li, Lanlan Niu, Ranran Cao & Weiping Yin

School of Chemical Engineering and Pharmaceutics, Henan University of Science and Technology, Luoyang, Henan 471023, P.R. China.


The excretions/secretions from the maggot of Chrysomyis megacephala Fabricius are traditionally used to treat serious infections in China. In this study, bioassay-guided fractionation led to the isolation of three novel antibacterial compounds (13), including important fluorinated compounds (3 and 5), together with other nine known compounds from 70% methanol extract of C. megacephala. The structures of the new compounds were elucidated by NMR spectroscopic analysis and high-resolution mass spectroscopy. The antibacterial activities of the isolated compounds were evaluated using agar disc diffusion method. New compounds 1 and 2 exhibited moderate activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) of 250 μg mL− 1. The most active compounds 3 and 5 displayed a broad spectrum of antimicrobial activity with an MIC of 125 μg mL− 1 against G+ and G−  bacteria. The structure of the above-mentioned novel compounds and their antimicrobial activities are herein reported for the first time from the natural product of insects.

Keywords: new compounds, insect's natural products, antimicrobial activity, Chrysomyis megacephala Fabricius, maggot (Wuguchong).

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