Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Research on Microbes
Microbiology Experts
Online Submission
Access Statistics

Site Visitors

blog tracking

Microbial Pathogenesis
Volume 123, 2018, Pages: 527-535

Identification and isolation of antimicrobial compounds from the flower extract of Hibiscus rosa-sinensis L: In silico and in vitro approaches

S.Vijayakumar, J.E.Morvin Yabesh, P.Arulmozhi, P.K.Praseetha

Computational Phytochemistry Lab, PG and Research Department of Botany and Microbiology, AVVM Sri Pushpam College (Autonomous) Poondi, Thanjavur (Dist), Tamil Nadu, India.


The modern people are preparing the natural medicines from the plants and their parts for curing various diseases. The present study was chosen Hibiscus rosa-sinensis flowers to analyze its antimicrobial capabilities against venereal diseases causing pathogens. In this study, the antimicrobial activity performed in different solvents prepared flower extracts using agar well diffusion method. Among the extracts, the methanolic flower extract of Hibiscus rosa-sinensis shows better results than other solvents extracts. The extract analysed by GC-MS which was exposes seven bioactive molecules. These bioactive molecules were docked with N. gonorrhoea protein. Finally, benzene dicarboxylic acid had best glide docking XP scores −7.955 with better binding energy values (−38.692 kcal/mol) than other ligand molecules. Hence, this molecule was isolated from the flowers of H. rosa-sinensis. After that, the different concentrations of 1,2 benzene dicarboxylic acid were tested on human diseases causing microbial strains. There, all the levels were showed good anti-gonorrhoeal activity against N. gonorrhoeae. Hence this study suggested that 1,2 benzene dicarboxylic acid could be used as a better drug candidate for venereal diseases.

Keywords: Hibiscus rosa-sinensis, GC-MS, Neisseria gonorrhoea, Molecular docking, 12 benzenedicarboxylic acids, UV, FTIR, NMR.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution