High Ionic Strength Formation of DOPA-Melanin Coating for Loading and Release of Cationic Antimicrobial Compounds
Jinghao Kuang, Jason L. Guo and Phillip B. Messersmith
Biomedical Engineering Department, Northwestern University, Evanston, IL, USA.
Conformal DOPA-melanin films are formed on a variety of substrates by simple dip-coating in an alkaline DOPA solution at high ionic strength. Compared to polydopamine, DOPA-melanin coatings have the advantage of high hydrophilicity and also the ability to bind and release cations. The latter is demonstrated by using DOPA-melanin coated polycarbonate to form an antibacterial surface that inhibits and kills S. aureus.
Keywords:DOPA melanin; coating; antimicrobial; gentamicin; Staphylococcus aureus.