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Advances in Medical Sciences
Vol. 63 (1), 2018, Pages: 14-21


Cytotoxic, genotoxic and antimicrobial activity of caffeic and rosmarinic acids and their lithium, sodium and potassium salts as potential anticancer compounds

Ahmed Nada, Marwa Al-Moghazy, Ahmed A.F.Soliman, Gehan M.T.Rashwan, Taghreed Hosny Ahmed Eldawy, Ashraf Abd Elhakim Hassan, Galal Hosni Sayed

Pretreatment & Finishing of Cellulose Based Textiles Dept., Textile Research Division, National Research Centre, Dokki, Giza, Egypt.

Abstract

The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-Phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] and 1H- pyrazole-3 (1), 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (2) were synthesized, characterized and encapsulated into liposomal chitosan emulsions for textile finishing. The chemical modifications of cotton fabrics were demonstrated by infrared analysis. Retention of the fabric mechanical properties was investigated by reporting the tensile strength values. Synthesized pyrazole-based compounds were screened for cytotoxicity against skin fibroblast cell line and showed very limited toxicity for both compounds. Antimicrobial potentials of the treated cotton fabrics were tested against bacterial strains E. coli ATCC 8379 and Staphylococcus aureus ATCC 25923.

Keywords: Lecithin, Emulsion, Cotton fabric, Wet process, Pharmacological.

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