Aminopropyl-silica functionalized with halogen-reactive compounds for antimicrobial applications
Irina Zarafua, Ali Abed Jebur Al Taweela, Carmen Limbanb, Marcela Popac, Lumini?a Maru?escuc, Mariana Carmen Chifiriucc, Gratiela Gradisteanu Pircalabioruc, Daniela Culi?ad, Corneliu Ghicae, Petre Ionitaa
University of Bucharest, Faculty of Chemistry, Panduri 90-92, Bucharest, Romania.
Aminopropyl-silica nanoparticles S0 were obtained and further functionalized with eight halogen-reactive organic compounds 1–8, leading to the S1–S8 hybrid organic-inorganic materials, with spherical morphology and having a 50–200 nm size, as showed TEM analysis. These were further characterized by IR and DLS. Biological assays were performed using five microbial strains, belonging to species frequently encountered in the aetiology of human infections (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans). The obtained materials exhibited promising antimicrobial properties, being active against planktonic, but particularly on biofilm-embedded cells. Among the tested hybrid nanomaterials, S6 seemed to exhibit the most promising antimicrobial profile.
Keywords: Synthesis, Structural analysis, Biological evaluation, Nanoparticle, Silica.